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Physical activity of mice on dietary sulfur amino acid restriction is influenced by age of diet init
Sulfur amino acid restriction (SAAR)-the reduction of methionine and cysteine concentrations either in the diet or by genetic...
OFAS
Dec 4, 2023
Cystine rather than cysteine is the preferred substrate for β-elimination by cystathionine γ-lyase:
Dietary methionine restriction (MR) increases longevity by improving health. In experimental models, MR is accompanied by decreased cystathionine β-synthase activity and increased cystathionine γ-lyase activity. These enzymes are parts of the transsulfuration pathway which produces cysteine and 2-oxobutanoate. Thus, the decrease in cystathionine β-synthase activity is likely to account for the loss of tissue cysteine observed in MR animals. Despite this decrease in cysteine l
OFAS
May 24, 2023
Dietary Methionine and Total Sulfur Amino Acid Restriction in Healthy Adults
Dietary Methionine and Total Sulfur Amino Acid Restriction in Healthy Adults Objectives: Dietary restriction of methionine (Met) and...
OFAS
Mar 1, 2023
Effects of dietary methionine restriction on age-related changes in perivascular and beiging adipose
Effects of dietary methionine restriction on age-related changes in perivascular and beiging adipose tissues in the mouse Objective: ...
OFAS
Dec 14, 2022
Cysteine restriction-specific effects of sulfur amino acid restriction on lipid metabolism
Cysteine restriction-specific effects of sulfur amino acid restriction on lipid metabolism Decreasing the dietary intake of methionine...
OFAS
Nov 28, 2022
Cumulative consumption of sulfur amino acids and risk of diabetes: a prospective cohort study
Cumulative consumption of sulfur amino acids and risk of diabetes: a prospective cohort study Cross-sectional studies suggested that...
OFAS
Oct 12, 2022
Intermittent methionine restriction reduces IGF-1 levels and produces similar healthspan benefits to
A sustained state of methionine restriction (MR) dramatically extends the healthspan of several model organisms. For example,...
OFAS
Jun 6, 2022
Sulfur Amino Acid-Restricted Diets: Mechanisms and Health Benefits
#Ables #agingresearch #sulfuraminoacids
OFAS
Sep 23, 2021
Selenium supplementation inhibits IGF-1 signaling and confers methionine restriction-like healthspan
#agingresearch #Johnson #sulfuraminoacids
OFAS
Mar 30, 2021
Differential effects of sulfur amino acid-restricted and low-calorie diets on gut microbiome profile
#agingresearch #Nichenametla #sulfuraminoacids
OFAS
Jan 1, 2021
Age-at-onset-dependent effects of sulfur amino acid restriction on markers of growth and stress in m
#agingresearch #Nichenametla #sulfuraminoacids
OFAS
Jul 13, 2020
Weight loss and concomitant adipose autophagy in methionine-restricted obese mice is not dependent o
#Ables #methioninerestriction #Nichenametla #obesity
OFAS
May 4, 2020
Methionine restriction delays aging-related urogenital diseases in male Fischer 344 rats
Despina Komninou, Virginia L. Malloy, Jay A. Zimmerman, Raghu Sinha, John P. Richie Jr. GeroScience. 2020 Feb PMID: 31728897 Dietary...
OFAS
Dec 23, 2019
Extension of cellular lifespan by methionine restriction involves alterations in central carbon meta
#Johnson #lifespan #methioninerestriction
OFAS
Nov 6, 2019
Dietary methionine influences therapy in mouse cancer models and alters human metabolism.
Gao X, Sanderson SM, Dai Z, Reid MA, Cooper DE, Lu M, Richie JP Jr, Ciccarella A, Calcagnotto A, Mikhael PG, Mentch SJ, Liu J, Ables G,...
OFAS
Oct 17, 2019
Bone marrow adiposity: basic and clinical implications
Sebo ZL, Rendina-Ruedy E, Ables GP, Lindskog DM, Rodeheffer MS, Fazeli PK, Horowitz MC. Endocr Rev. 2019 Oct 1;40(5):1187-1206 PMID:...
OFAS
Oct 17, 2019
Identification and application of gene expression signatures associated with lifespan extension
Tyshkovskiy A, Bozaykut P, Borodinova AA, Gerashchenko MV, Ables GP, Garratt M, Khaitovich P, Clish CB, Miller RA, Gladyshev VN. Cell...
OFAS
Oct 17, 2019
Methionine metabolism influences genomic architecture and gene expression through H3K4me3 peak width
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OFAS
May 15, 2018
Disease prevention and delayed aging by dietary sulfur amino acid restriction: translational implica
#aging #Dong #methionine #SAAR
OFAS
Apr 1, 2018
Sulfur amino acid restriction-induced changes in redox-sensitive proteins are associated with slow p
Nichenametla SN, Mattocks DAL, Malloy VL, Pinto JT Ann. N. Y. Acad. Sci. 2018 Jan; PMID: 29377163 The mechanisms underlying life span...
OFAS
Jan 29, 2018
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