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Naturally occurring p16Ink4a-positive cells shorten healthy lifespan
Cellular senescence, a stress-induced state in which cells are unable to divide, is known to prevent the proliferation of potentially...
Nov 30, 2016
Dr. Gene Ables Invited to Speak at 13th International Symposium on Neurobiology and Neuroendocrinolo
13th International Symposium on Neurobiology and Neuroendocrinology of Aging July 17-22, 2016, Bregenz, Austria In keeping with our...
Jul 22, 2016
Methionine-restricted diet inhibits growth of MCF10AT1-derived mammary tumors by increasing cell cyc
Past research has shown that dietary methionine restriction (MR) improves healthspan in part by reducing fat and increasing insulin...
Jul 22, 2016
Welcome to Healthspan!
Fifty-five years ago, when my father Dr. Norman Orentreich founded OFAS, his research focused on wound healing and aging studies. Over...
Jul 21, 2016
Impact of dietary resistant starch type 4 on human gut microbiota and immunometabolic functions
#adipokines #metabolicsyndrome #Nichenametla
Jun 30, 2016
Methionine-restricted diet increases miRNAs that can target RUNX2 expression and alters bone structu
Plummer J, Park M, Perodin F, Horowitz MC, Hens JR J. Cell. Biochem. 2016 May; PMID: 27191548 Dietary methionine restriction (MR)...
May 17, 2016
Methionine restriction alters bone morphology and affects osteoblast differentiation
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Apr 18, 2016
Upcoming Symposium: Aging and Nutrition: Novel Approaches and Techniques
Several interventions have been identified that significantly extend healthy lifespan in mammals. Caloric restriction, for example, has...
Feb 15, 2016
Dietary restrictions, bone density, and bone quality
Huang TH, Ables GP Ann. N. Y. Acad. Sci. 2016 Jan;1363(1):26-39 PMID: 26881697 Caloric restriction (CR), protein restriction (PR), and...
Jan 1, 2016
Methionine restriction beyond life-span extension
Ables GP, Hens JR, Nichenametla SN Ann. N. Y. Acad. Sci. 2016 Jan;1363(1):68-79 PMID: 26916321 Dietary methionine restriction (MR)...
Jan 1, 2016
Methionine-restricted diet inhibits growth of MCF10AT1-derived mammary tumors by increasing cell cyc
Hens JR, Sinha I, Perodin F, Cooper T, Sinha R, Plummer J, Perrone CE, Orentreich D BMC Cancer 2016;16(1):349 PMID: 27255182 BACKGROUND:...
Dec 31, 2015
Histone methylation dynamics and gene regulation occur through the sensing of one-carbon metabolism
Mentch SJ, Mehrmohamadi M, Huang L, Liu X, Gupta D, Mattocks D, Gόmez Padilla P, Ables G, Bamman MM, Thalacker-Mercer AE, Nichenametla...
Oct 31, 2015
Effects of methionine restriction and endurance exercise on bones of ovariectomized rats: a study of
Huang TH, Su IH, Lewis JL, Chang MS, Hsu AT, Perrone CE, Ables GP J. Appl. Physiol. 2015 Sep;119(5):517-26 PMID: 26159761 To investigate...
Aug 31, 2015
Dietary methionine restriction in mice elicits an adaptive cardiovascular response to hyperhomocyste
Ables GP, Ouattara A, Hampton TG, Cooke D, Perodin F, Augie I, Orentreich DS Sci Rep 2015;5:8886 PMID: 25744495 Dietary methionine...
Jan 1, 2015
Dietary methionine restriction inhibits prostatic intraepithelial neoplasia in TRAMP mice
Sinha R, Cooper TK, Rogers CJ, Sinha I, Turbitt WJ, Calcagnotto A, Perrone CE, Richie JP Prostate 2014 Dec;74(16):1663-73 PMID: 25250521 ...
Nov 30, 2014
Resistant starch type 4-enriched diet lowered blood cholesterols and improved body composition in a
#geneexpression #Nichenametla #polymorphism
Jun 1, 2014
Methionine restriction activates the retrograde response and confers both stress tolerance and lifes
#agingresearch #Johnson #methioninerestriction #sulfuraminoacids
May 15, 2014
A methionine-restricted diet and endurance exercise decrease bone mass and extrinsic strength but in
Huang TH, Lewis JL, Lin HS, Kuo LT, Mao SW, Tai YS, Chang MS, Ables GP, Perrone CE, Yang RS J. Nutr. 2014 May;144(5):621-30 PMID: 24647387...
Apr 30, 2014
The First International Mini-Symposium on Methionine Restriction and Lifespan
Ables GP, Brown-Borg HM, Buffenstein R, Church CD, Elshorbagy AK, Gladyshev VN, Huang TH, Miller RA, Mitchell JR, Richie JP, Rogina B,...
Jan 1, 2014
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