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Physical activity of mice on dietary sulfur amino acid restriction is influenced by age of diet init
Sulfur amino acid restriction (SAAR)-the reduction of methionine and cysteine concentrations either in the diet or by genetic...
OFAS
Dec 4, 2023
Cystine rather than cysteine is the preferred substrate for β-elimination by cystathionine γ-lyase:
Dietary methionine restriction (MR) increases longevity by improving health. In experimental models, MR is accompanied by decreased cystathionine β-synthase activity and increased cystathionine γ-lyase activity. These enzymes are parts of the transsulfuration pathway which produces cysteine and 2-oxobutanoate. Thus, the decrease in cystathionine β-synthase activity is likely to account for the loss of tissue cysteine observed in MR animals. Despite this decrease in cysteine l
OFAS
May 24, 2023
Dietary Methionine and Total Sulfur Amino Acid Restriction in Healthy Adults
Dietary Methionine and Total Sulfur Amino Acid Restriction in Healthy Adults Objectives: Dietary restriction of methionine (Met) and...
OFAS
Mar 1, 2023
Effects of dietary methionine restriction on age-related changes in perivascular and beiging adipose
Effects of dietary methionine restriction on age-related changes in perivascular and beiging adipose tissues in the mouse Objective: ...
OFAS
Dec 14, 2022
Cysteine restriction-specific effects of sulfur amino acid restriction on lipid metabolism
Cysteine restriction-specific effects of sulfur amino acid restriction on lipid metabolism Decreasing the dietary intake of methionine...
OFAS
Nov 28, 2022
Sulfur Amino Acid-Restricted Diets: Mechanisms and Health Benefits
#Ables #agingresearch #sulfuraminoacids
OFAS
Sep 23, 2021
Weight loss and concomitant adipose autophagy in methionine-restricted obese mice is not dependent o
#Ables #methioninerestriction #Nichenametla #obesity
OFAS
May 4, 2020
Dietary methionine influences therapy in mouse cancer models and alters human metabolism.
Gao X, Sanderson SM, Dai Z, Reid MA, Cooper DE, Lu M, Richie JP Jr, Ciccarella A, Calcagnotto A, Mikhael PG, Mentch SJ, Liu J, Ables G,...
OFAS
Oct 17, 2019
Bone marrow adiposity: basic and clinical implications
Sebo ZL, Rendina-Ruedy E, Ables GP, Lindskog DM, Rodeheffer MS, Fazeli PK, Horowitz MC. Endocr Rev. 2019 Oct 1;40(5):1187-1206 PMID:...
OFAS
Oct 17, 2019
Identification and application of gene expression signatures associated with lifespan extension
Tyshkovskiy A, Bozaykut P, Borodinova AA, Gerashchenko MV, Ables GP, Garratt M, Khaitovich P, Clish CB, Miller RA, Gladyshev VN. Cell...
OFAS
Oct 17, 2019
Bone marrow adipocytes.
Horowitz MC, Berry R, Holtrup B, Sebo Z, Nelson T, Fretz JA, Lindskog D, Kaplan JL, Ables GP, Rodeheffer MS, Rosen CJ. Adipocyte. 2017...
OFAS
Dec 5, 2017
Dietary methionine restriction modulates renal response and attenuates kidney injury in mice
Cooke D, Ouattara A, Ables GP FASEB J. 2017 Oct. PMID: 28970255 Methionine restriction (MR) extends the lifespan across several species,...
OFAS
Oct 3, 2017
Pleiotropic responses to methionine restriction
Ables GP, Johnson JE Exp. Gerontol. 2017 Jan; PMID: 28108330 Methionine restriction (MR) extends lifespan across different species. The...
OFAS
Jan 17, 2017
Methionine restriction alters bone morphology and affects osteoblast differentiation
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OFAS
Apr 18, 2016
Dietary restrictions, bone density, and bone quality
Huang TH, Ables GP Ann. N. Y. Acad. Sci. 2016 Jan;1363(1):26-39 PMID: 26881697 Caloric restriction (CR), protein restriction (PR), and...
OFAS
Jan 1, 2016
Methionine restriction beyond life-span extension
Ables GP, Hens JR, Nichenametla SN Ann. N. Y. Acad. Sci. 2016 Jan;1363(1):68-79 PMID: 26916321 Dietary methionine restriction (MR)...
OFAS
Jan 1, 2016
Histone methylation dynamics and gene regulation occur through the sensing of one-carbon metabolism
Mentch SJ, Mehrmohamadi M, Huang L, Liu X, Gupta D, Mattocks D, Gόmez Padilla P, Ables G, Bamman MM, Thalacker-Mercer AE, Nichenametla...
OFAS
Oct 31, 2015
Effects of methionine restriction and endurance exercise on bones of ovariectomized rats: a study of
Huang TH, Su IH, Lewis JL, Chang MS, Hsu AT, Perrone CE, Ables GP J. Appl. Physiol. 2015 Sep;119(5):517-26 PMID: 26159761 To investigate...
OFAS
Aug 31, 2015
Dietary methionine restriction in mice elicits an adaptive cardiovascular response to hyperhomocyste
Ables GP, Ouattara A, Hampton TG, Cooke D, Perodin F, Augie I, Orentreich DS Sci Rep 2015;5:8886 PMID: 25744495 Dietary methionine...
OFAS
Jan 1, 2015
A methionine-restricted diet and endurance exercise decrease bone mass and extrinsic strength but in
Huang TH, Lewis JL, Lin HS, Kuo LT, Mao SW, Tai YS, Chang MS, Ables GP, Perrone CE, Yang RS J. Nutr. 2014 May;144(5):621-30 PMID: 24647387...
OFAS
Apr 30, 2014
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