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Bringing Methionine Restriction to the Masses — Is It Possible?
Methionine restriction (MR) has been known for decades to extend lifespan across multiple organisms, dating back to the seminal publication Low Methionine Ingestion by Rats Extends Life Span (N. Orentreich et al). Unlike other pro-longevity interventions—such as calorie restriction, intermittent fasting, or ketogenic diets—MR has yet to gain traction among health-conscious individuals. This is largely due to the overabundance of methionine in most dietary protein sources, mak
Jason Plummer
6 days ago
Combating Chronic Inflammation: IL-11 as a Key to Longer, Healthier Lives
By delving into the mechanisms that drive and are driven by low-level inflammation, a new study reveals potential pathways for developing an
OFAS
Oct 3, 2024
Revolutionizing Age-Related Disease Management: The Promise of Senolytic CAR T Cells
Recent developments in immunotherapy offer a glimmer of hope in the pursuit of longevity and the alleviation of age-related diseases. Utilizing engineered chimeric antigen receptor T (CAR T) cells, a recent study has shed light on a promising new approach to combating the effects of aging, particularly metabolic dysfunction and decreased physical fitness (Amor C, Fernández-Maestre I, Chowdhury S. et al. Prophylactic and long-lasting efficacy of senolytic CAR T cells against
OFAS
Mar 7, 2024
Intermittent Methionine Restriction: A Superior Approach to Bone Health
An intermittently methionine-restricted diet reduces marrow fat accumulation and preserves more bone mass than continuous methionine restriction, according to a recent study from the Johnson Lab published in Aging Biology . Methionine restriction (MR) is known to increase the lifespan of multiple species, with an increase of up to 45% observed in rodents. The believed mechanism behind this benefit is the lowering of the hormone IGF-1. In addition to increasing lifespan, MR ha
OFAS
Feb 28, 2024
Canine Companions: Paving the Way for Human Aging Treatments
The FDA has approved a phase I clinical trial to test LOY-003, a novel therapeutic compound to delay aging in dogs. Why is this so...
OFAS
Feb 8, 2024
Physical activity of mice on dietary sulfur amino acid restriction is influenced by age of diet init
Sulfur amino acid restriction (SAAR)-the reduction of methionine and cysteine concentrations either in the diet or by genetic...
OFAS
Dec 4, 2023
Unlocking the Secrets of Naked Mole-Rats: Pro-longevity Effects of Hyaluronic Acid
Naked mole-rats, those peculiar-looking creatures that live in underground colonies, have fascinated scientists for years. Although...
OFAS
Nov 27, 2023
Putting the Brakes on DNA Transcription to Slow the Aging Process
[et_pb_section][et_pb_row][et_pb_column type=”4_4″][et_pb_text]In the pursuit of unraveling the mysteries of aging, researchers have long...
OFAS
Jul 20, 2023
Hungry for Lifespan Extension: Researchers Unravel the Role of Hunger in Aging
Hunger, an innate physiological sensation, has played a crucial role throughout human evolution, ensuring survival by driving individuals...
OFAS
Jun 30, 2023
Waiting for the Next Therapy to Extend Lifespan? You Might Have to Hold Your Breath
In the realm of scientific understanding, few discoveries have had as profound an impact on our comprehension of life’s sustenance as...
OFAS
Jun 12, 2023
Cystine rather than cysteine is the preferred substrate for β-elimination by cystathionine γ-lyase:
Dietary methionine restriction (MR) increases longevity by improving health. In experimental models, MR is accompanied by decreased cystathionine β-synthase activity and increased cystathionine γ-lyase activity. These enzymes are parts of the transsulfuration pathway which produces cysteine and 2-oxobutanoate. Thus, the decrease in cystathionine β-synthase activity is likely to account for the loss of tissue cysteine observed in MR animals. Despite this decrease in cysteine l
OFAS
May 24, 2023
Sailendra Nichenametla Recipient of Inaugural Hevolution/AFAR New Investigator Award in Aging Biolog
Senior Scientist Sailendra Nichenametla, Ph.D., has been named as a recipient of the inaugural Hevolution/AFAR New Investigator Awards...
OFAS
Apr 24, 2023
Serine Supplementation Could Mitigate Cognitive Impairments of an Aging Hypothalamus
The hypothalamus is an area of the brain responsible for regulating a wide range of bodily functions, including metabolism, body...
OFAS
Apr 17, 2023
Can Ultrasound Therapy Delay Aging?
Senescence and Aging In 1961, Leonard Hayflick first observed that cultured cells ceased replicating after a finite number of divisions....
OFAS
Mar 7, 2023
Dietary Methionine and Total Sulfur Amino Acid Restriction in Healthy Adults
Dietary Methionine and Total Sulfur Amino Acid Restriction in Healthy Adults Objectives: Dietary restriction of methionine (Met) and...
OFAS
Mar 1, 2023
New Study Supports the “Information Theory of Aging” and Its Potential to Combat Aging
The information theory of aging suggests that aging results from the accumulation of errors in an organism’s genetic code over its...
OFAS
Feb 9, 2023
Intermittent Fasting Shown to Effectively Treat Type 2 Diabetes
A recent study published in The Journal of Clinical Endocrinology & Metabolism has shown a dietary approach that might reverse type 2...
OFAS
Jan 12, 2023
Effects of dietary methionine restriction on age-related changes in perivascular and beiging adipose
Effects of dietary methionine restriction on age-related changes in perivascular and beiging adipose tissues in the mouse Objective: ...
OFAS
Dec 14, 2022
A Modified Mediterranean Diet Reduces Unhealthy Visceral Fat
The Mediterranean diet—high in nuts, olive oil, and vegetables with a moderately reduced but varied consumption of fish, meat, and...
OFAS
Dec 7, 2022
2022 OFAS Report of Directors
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OFAS
Dec 5, 2022
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