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Cystine rather than cysteine is the preferred substrate for β-elimination by cystathionine γ-lyase:
Dietary methionine restriction (MR) increases longevity by improving health. In experimental models, MR is accompanied by decreased cystathionine β-synthase activity and increased cystathionine γ-lyase activity. These enzymes are parts of the transsulfuration pathway which produces cysteine and 2-oxobutanoate. Thus, the decrease in cystathionine β-synthase activity is likely to account for the loss of tissue cysteine observed in MR animals. Despite this decrease in cysteine l
OFAS
May 24, 2023
Dietary Methionine and Total Sulfur Amino Acid Restriction in Healthy Adults
Dietary Methionine and Total Sulfur Amino Acid Restriction in Healthy Adults Objectives: Dietary restriction of methionine (Met) and...
OFAS
Mar 1, 2023
Cysteine restriction-specific effects of sulfur amino acid restriction on lipid metabolism
Cysteine restriction-specific effects of sulfur amino acid restriction on lipid metabolism Decreasing the dietary intake of methionine...
OFAS
Nov 28, 2022
Association of sulfur amino acid consumption with cardiometabolic risk factors: Cross-sectional find
#diabetes #Cardiometabolicdiseases #methionine #Dong #SAAR #sulfuraminoacids #cysteine
OFAS
Feb 3, 2020
Sulfur amino acid restriction–induced changes in redox-sensitive proteins are associated with slow p
Optimal maintenance of protein quality is critical for proper cellular functions. Protein turnover (PT) is a critical contributor to...
OFAS
Feb 16, 2018
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