Recent developments in immunotherapy offer a glimmer of hope in the pursuit of longevity and the alleviation of age-related diseases. Utilizing engineered chimeric antigen receptor T (CAR T) cells, a recent study has shed light on a promising new approach to combating the effects of aging, particularly metabolic dysfunction and decreased physical fitness (Amor C, Fernández-Maestre I, Chowdhury S. et al. Prophylactic and long-lasting efficacy of senolytic CAR T cells against