Methionine restriction delays aging-related urogenital diseases in male Fischer 344 rats

Despina Komninou, Virginia L. Malloy, Jay A. Zimmerman, Raghu Sinha, John P. Richie Jr.

GeroScience. 2020 Feb

PMID: 31728897

Dietary methionine restriction (MR) has been found to enhance longevity across many species. We hypothesized that MR might enhance longevity in part by delaying or inhibiting age-related disease processes. To this end, male Fischer 344 rats were fed control (CF, 0.86% methionine) or MR (0.17% methionine) diets throughout their life until sacrifice at approximately 30 months of age, and histopathology was performed to identify the incidence and progression of two important aging-related pathologies, namely, chronic progressive nephropathy (CPN) and testicular tumorigenesis. Although kidney pathology was observed in 87% CF rats and CPN in 62% of CF animals, no evidence of kidney disease was observed in MR rats. Consistent with the absence of renal pathology, urinary albumin levels were lower in the MR group compared to controls throughout the study, with over a six-fold difference between the groups at 30 months of age. Biomarkers associated with renal disease, namely, clusterin, cystatin C, and β-2 microglobulin, were reduced following 18 months of MR. A reduction in testicular tumor incidence from 88% in CF to 22% in MR rats was also observed. These results suggest that MR may lead to metabolic and cellular changes providing protection against age-related diseases.

OFAS Successfully Hosted AGA Session

OFAS Successfully Hosted AGA Session

This year, OFAS hosted a pre-meeting session at the AGE 47th Annual Meeting in Philadelphia. The theme of the conference was “Improving Resiliency to Delay Aging”, and the OFAS-sponsored session was focused on Nutrition and Longevity. The panel of speakers included: Dr. Sebastian Brandhorst from University of Southern California; Dr. John Newman from the Buck Institute and UCSF; Dr. John P. Richie from Penn State University; and Dr. Brian Kennedy from the Yong Loo Lin School of Medicine at the National University of Singapore. There were 261 attendees present at the meeting, including some directors for the Nathan Shock Centers and NIH-NIA.

For years, Orentreich Foundation for the Advancement of Science has researched biomedical interventions to prevent, halt, or reverse those disorders that decrease the quality or length of life. Our groundbreaking research on dietary methionine restriction has shown its dramatic ability to increase longevity while improving healthspan, lowering body weight, and reducing the incidence of age-related diseases.

In addition to our dedication to discovery, we are also committed to promoting the exchange of knowledge and strengthening of relationships within the scientific community. We host a biennial symposium on healthy aging, support meetings in the field, and, each year, our scientists represent us at conferences and seminars around the globe.