The integrated stress response in budding yeast lifespan extension

The integrated stress response in budding yeast lifespan extension

mic-04-368-g01The ultimate goal of aging research is to develop therapeutic means to extend human lifespan, while reducing susceptibility to many age-related diseases including cancer, as well as metabolic, cardiovascular and neurodegenerative disorders. However, this first requires clarification of the causes of aging, which has been greatly facilitated by the use of model organisms. In particular, the budding yeast Saccharomyces cerevisiae has been vital in the identification of conserved molecular and cellular determinants of aging and for the development of approaches to manipulate these aging determinants to extend lifespan. Past studies have shown that all means to experimentally extend lifespan result in the initiation of cellular stress responses which, in turn, increases the process of autophagy.

This review describes growing evidence in yeast that activation of the integrated stress response contributes significantly to lifespan extension. Thus, therapeutics to directly activate autophagy could be another promising approach to extend lifespan and healthspan. There are many different types of autophagy, and in order to have a better understanding of the aging process, it is crucial to know the specific autophagy pathways that need to be activated in order to extend yeast lifespan. This could then lead to the discovery of pharmaceutical and physiological regulators of these processes in yeast, which will likely have biological significance to human health and aging. It should also be noted that the impressive pace of research and discoveries being made using the yeast model organism indicate that it will continue to be a central model for aging studies in the near future.

You can find the full paper here.

2016 OFAS Report of Directors

2016 OFAS Report of Directors


As we conclude our 55th year, we at the Orentreich Foundation for the Advancement of Science (OFAS) are reminded of how grateful we are for our friends around the globe. We are pleased with the advances in our research this past year and for the success of our symposia series in gathering fellow scientists to share progress and ideas. We are confident that our gatherings will continue support advancement in the field of aging.

We hope you will consider investing in OFAS’s research efforts with a donation. With each day that passes, advancements are made toward the goal of extending healthy lifespan, and each day OFAS is able to be a part of this work because of friends like you.

To view our recently published our 2016 Report of Directors, click here.

Thank you for your part in making OFAS’s 2016 such a success!


Dr. O's Sig       David O Sig
Norman Orentreich, MD, FACP                          David S. Orentreich, MD
Founder and Co-Director                                     Co-Director