As part of our commitment to promoting the exchange of knowledge and strengthening relationships in the scientific community, OFAS hosts a series of symposia that focus on issues concerning diet and aging. For the first time, we are working with the National Institute on Aging (Bethesda, Md.), jointly developing the content and scope of the current Workshop.

Dr. Dudley Lamming (University of Wisconsin-Madison) will give the keynote address: Beyond the calorie: The regulation of health and longevity by specific dietary amino acids.

2:00 pm – 2:15 pm Welcome
2:15 pm – 3:45 pm Mechanistic studies of healthspan-extending interventions in cultured cells
2:15 – 2:50 Mechanisms of yeast chronological lifespan extension by amino acid supplementation
Jeff Smith, Ph.D., University of Virginia School of Medicine
2:50 – 3:25 Molecular mechanisms of lifespan extension and the struggle to bring them to the clinic
Christian Sell, Ph.D., Drexel University College of Medicine
3:25 – 3:45 Panel Discussion
4:00 pm – 6:15 pm
Emerging concepts in dietary restriction and healthspan
4:00 – 4:35 The protein paradox—resolving the roles of dietary protein in obesity, aging, and age-related disease
Stephen Simpson, Ph.D, The University of Sydney
4:35 – 5:10 Heterogeneity in the impact of dietary protein on metabolic health highlights the importance of precision dietetics
Cara Green, Ph.D., University of Wisconsin–Madison
5:10 – 5:45 Methionine metabolism and growth hormone: Impact on aging
Holly Brown-Borg, Ph.D., University of North Dakota School of Medicine
5:45 – 6:15 Panel Discussion
7:00 pm – 8:30 pm Banquet Dinner with Keynote Address
  Beyond the calorie: The regulation of health and longevity by specific dietary amino acids
Dudley Lamming, Ph.D., University of Wisconsin–Madison


9:00 am – 11:15 am Mechanistic studies of healthspan-extending interventions in rodents
9:00 – 9:35 The effects of sulfur amino acid restriction on the SOD1-G93A mouse model for amyotrophic lateral sclerosis (ALS)
Gene Ables, Ph.D., OFAS
9:35 – 10:10 A comparison of the effects of caloric and sulfur amino acid restrictions in male F344 rats
Sailendra Nath Nichenametla, Ph.D., OFAS
10:10 – 10:45 Novel amino acid-related dietary interventions that improve the healthspan of mice
Jay Johnson, Ph.D., OFAS
10:45 – 11:15 Panel Discussion
11:30 am – 1:45 pm
Advances and challenges in translating dietary and pharmacological interventions
11:30 – 12:05 New insights into the translational potential of rapamycin to target biological aging
Matt Kaeberlein, Ph.D., Optispan, Inc. and University of Washington
12:05 – 12:40 Randomized dietary methionine and total sulfur amino acid restriction in healthy adults
Raghu Sinha, Ph.D., Penn State College of Medicine
12:40 – 1:15 Dietary sulfur amino acid restriction in men and women with overweight and obesity: Evidence from a double-blind, randomized controlled dietary intervention study
Thomas Olsen, Ph.D., University of Oslo
1:15 – 1:45 Panel Discussion
1:45 pm – 2:00 pm Closing Remarks


Workshop Sessions:
Natcher E1/E2
NIH Bethesda Campus

The Bethesdan Hotel
8120 Wisconsin Ave, Bethesda


Angela Tremain