Researchers Find Reversible Cause of Vascular Aging
The hallmarks of aging in skeletal muscle include endothelial cell dysfunction, impaired microcapillary formation, and a progressive decline in exercise capacity, yet the underlying causes of these symptoms are poorly understood. In a recent paper, researchers...
Can Drugs Delay the Onset of Age-Related Diseases?
Over the past ten years, understanding of the physiological changes that occur as people age has greatly improved. Common mechanisms seem to support several age-related diseases, including diabetes, Parkinson’s disease and Alzheimer’s. A review of more than 400...
Sulfur amino acid restriction–induced changes in redox-sensitive proteins are associated with slow protein synthesis rates
Optimal maintenance of protein quality is critical for proper cellular functions. Protein turnover (PT) is a critical contributor to protein integrity and serves other functions, such as providing amino acids during starvation or dietary deficiency. By controlling the...
The role of autophagy in the regulation of yeast life span
Aging is a complex, multifactorial process that is driven by the progressive accumulation of several types of cellular damage. Functional impairment at the cellular level causes a multitude of pathologies and disorders in aged individuals. The goal of the aging field...
2017 OFAS Report of Directors
As we begin the new year, we at the Orentreich Foundation for the Advancement of Science (OFAS) are reminded of how grateful we are for our friends around the globe. We are pleased with the advances in our research this past year and for the success of our symposia...
The integrated stress response in budding yeast lifespan extension
The ultimate goal of aging research is to develop therapeutic means to extend human lifespan, while reducing susceptibility to many age-related diseases including cancer, as well as metabolic, cardiovascular and neurodegenerative disorders. However, this first...
MR Reduces the Effects of Kidney Injury
Did you know that kidney disease is one of the major causes of early mortality, morbidity, and rising medical costs in the United States? Now, more than ever, it is crucial to find a way to delay or avoid this devastating disease. OFAS and other researchers have...
High Fat Diet Improves Healthspan and Memory
A recent study has demonstrated that a ketogenic diet significantly improved memory in aging mice and increased the animal’s chances of surviving to old age, opening up a new area of inquiry in aging research. Eating a ketogenic diet – which is high in fat and low in...
High Fat Diet Extends Longevity and Healthspan
As more people age well past their 70s, researchers have increasingly explored the issues of health and quality of life during aging. A recent mouse study at the UC Davis School of Veterinary Medicine sheds revealed that a high-fat, or ketogenic, diet not only...
Cellular Rejunevation – One Step Closer to Understanding Human Aging
In order to delay aging, the process of aging must first be understood; that the aging of cells is what drives the aging of an organism. Recent aging research studies have shown that cellular aging and asymmetric cell division are intimately linked. Yeast has been the...