Can We Be Immunized Against Old Age?

Can We Be Immunized Against Old Age?

Can vaccines be used to fight age-related disease and, ultimately, to extend lifespan? Research published in Nature Aging suggests that such a promising strategy could be a reality.

Blood from Exercised Mice Supports the Brain Health of Sedentary Mice

Blood from Exercised Mice Supports the Brain Health of Sedentary Mice

When analyzed, the hippocampus, a region of the brain highly involved in learning and memory, showed increased neurogenesis in mice given access to running wheels for 28 days. In line with the increased cellular proliferation in the hippocampus, sedentary mice treated with “runner” plasma showed improved memory and cognition when assessed via standard behavioral tests.

2021 OFAS Report of Directors

As we begin the new year, we at the Orentreich Foundation for the Advancement of Science (OFAS) wish to thank our friends around the globe for their continued support. To view our recently published 2021 Report of the Director, click here. We hope you will consider...

Targeted Removal of Senescent Cells in Adipose Tissue Improves Type 2 Diabetes

Targeted Removal of Senescent Cells in Adipose Tissue Improves Type 2 Diabetes

Research has uncovered evidence that adipose cells are highly susceptible to senescence, an irreversible state of non-proliferation, and the accumulation of senescent cells with age leads to the senescence-associated secretory phenotype (SASP)—a deleterious inflammatory condition thought to be a critical driver of age-related diseases. Obesity and age are top risk factors for developing type 2 diabetes, and it would seem that therapies aimed at reducing SASP would be an ideal approach to improve this condition.

Fasting: The Critical Component of Calorie Restriction

Fasting: The Critical Component of Calorie Restriction

In 1935 Clive McCay published a paper demonstrating the pro-longevity effects of caloric restriction that would come to shape the future of longevity research. In McCay’s study, a simple 30% reduction of normal caloric intake was shown to impart robust gains in...

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