Can We Be Immunized Against Old Age?
Can vaccines be used to fight age-related disease and, ultimately, to extend lifespan? Research published in Nature Aging suggests that such a promising strategy could be a reality.
Blood from Exercised Mice Supports the Brain Health of Sedentary Mice
When analyzed, the hippocampus, a region of the brain highly involved in learning and memory, showed increased neurogenesis in mice given access to running wheels for 28 days. In line with the increased cellular proliferation in the hippocampus, sedentary mice treated with “runner” plasma showed improved memory and cognition when assessed via standard behavioral tests.
2021 OFAS Report of Directors
As we begin the new year, we at the Orentreich Foundation for the Advancement of Science (OFAS) wish to thank our friends around the globe for their continued support. To view our recently published 2021 Report of the Director, click here. We hope you will consider...
Erectile Dysfunction Pill Shows Promise as Alzheimer’s Disease Therapeutic
This retrospective case-control study revealed several drugs to be associated with decreased incidence of developing AD; sildenafil was by far the most promising candidate.
Targeted Removal of Senescent Cells in Adipose Tissue Improves Type 2 Diabetes
Research has uncovered evidence that adipose cells are highly susceptible to senescence, an irreversible state of non-proliferation, and the accumulation of senescent cells with age leads to the senescence-associated secretory phenotype (SASP)—a deleterious inflammatory condition thought to be a critical driver of age-related diseases. Obesity and age are top risk factors for developing type 2 diabetes, and it would seem that therapies aimed at reducing SASP would be an ideal approach to improve this condition.
Fasting: The Critical Component of Calorie Restriction
In 1935 Clive McCay published a paper demonstrating the pro-longevity effects of caloric restriction that would come to shape the future of longevity research. In McCay’s study, a simple 30% reduction of normal caloric intake was shown to impart robust gains in...
5-Minute Daily Breathing Therapy as Effective in Reducing High Blood Pressure and Risk of Cardiovascular Disease as 150 minutes per Week of Moderate Exercise
A modified version of a technique known as inspiratory muscle strength training (IMST), a therapy originally developed to treat pulmonary disorders (e.g., COPD, sleep apnea), is showing significant potential in replicating various effects of daily exercise with to regard to cardiovascular health.
Parasite Affords Extreme Lifespan to Ants
In a paper published in Royal Society Open Science, Beros et al. detail an example of the extreme lifespan extension imparted to normally short-lived worker ants that have been infected by the tapeworm Anomotaenia brevis.
Webinar for Aging Science Talks Chaired by Dr. Nichenametla
OFAS Associate Scientist Dr. Sailendra Nichenametla will chair a webinar, "Sulfur Amino Acid Restriction - Moving from Animals to Humans", for Aging Science Talks on October 20-21, 2021. The sessions will include presentations by Dr. Nichenametla, OFAS Associate...
Dr. Norman Orentreich Award for Young Investigator on Aging Presented to Cristal Hill
OFAS presented the second Dr. Norman Orentreich Award for Young Investigator on Aging to Dr. Cristal Hill of the Pennington Biomedical Research Center. In addition to the $1,000 prize, Cristal was invited to present at the 2021 OFAS Symposium on Healthy Aging.
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