In an attempt to understand secrets of longevity, researchers are focusing on the peculiar lifespan of ants, specifically queen ants. The typical lifespan of a worker ant is a modest 1 to 2 years; queen ants, however, can live up to 30 times longer. New research reveals the mechanism responsible for this extreme lifespan extension.
Research is increasingly producing novel pharmaceutical interventions to improve the quality and duration of human lifespan. Recent research explores a novel class of compounds designed to help sustain mitochondrial function in an effort to improve both lifespan and healthspan.
Evidence has emerged that cannabidiol (CBD), a non-hallucinogenic compound derived from the Cannabis sativa plant, extends the lifespan of specific animal models. A recent study examines the mechanisms by which it works.
OFAS presented the third Dr. Norman Orentreich Award for Young Investigator on Aging to Maximilian Schmid-Siegel, a Ph.D. candidate at the Medical University of Vienna Institute of Medical Genetics (Vienna, Austria). The award was presented at the 15th International...
An intermittent variation of the dietary intervention methionine restriction protects against obesity and provides additional metabolic health benefits to mice, according to a study from the Johnson Laboratory, recently published in Aging Cell.
Recent examination of crude extracts from plants utilized in traditional Chinese medicine has identified the herb Psoralea corylifolia to have potential lifespan-extending properties. Further analysis demonstrated a single compound, corylin, to be responsible for improving lifespan; it was shown to function through the mTOR pathway, a well-defined pathway known to modulate lifespan in a multitude of organisms.
A recent study from Stanford University School of Medicine demonstrates the partial restoration of brain function in old mice with infusions of cerebrospinal fluid from younger mice.
Since the development of technologies that have allowed humanity to outlive the “normal” period an organism is fit to survive in the natural world, the tragedy of old age and decrepitude has frustrated researchers and driven them to seek out a root cause. Progress has been achieved, for the most part, by addressing the discrete age-related pathologies; however, taking a first-principles approach focused on temperature has allowed researchers to investigate a basic temperature-dependent facet of aging and perhaps affect an underlying driver of many, if not all, age-related phenomena.
Thinking of biological aging as analogous to a clock, research has given us two distinct avenues of lifespan-extending intervention: the clock can be either slowed down or wound back. Most research has with dealt the former, but the latter is very promising—especially for those whose clock has been winding for some time.
Obesity is highly correlated with and thought to contribute to an increased incidence of heart disease, stroke, type 2 diabetes, and certain cancers and is rapidly becoming the most prevalent driver of age-related pathologies in the modern world. The availability of novel pharmaceutical interventions might provide treatment to the increasingly common condition of intractable obesity.
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