This retrospective case-control study revealed several drugs to be associated with decreased incidence of developing AD; sildenafil was by far the most promising candidate.
Research has uncovered evidence that adipose cells are highly susceptible to senescence, an irreversible state of non-proliferation, and the accumulation of senescent cells with age leads to the senescence-associated secretory phenotype (SASP)—a deleterious inflammatory condition thought to be a critical driver of age-related diseases. Obesity and age are top risk factors for developing type 2 diabetes, and it would seem that therapies aimed at reducing SASP would be an ideal approach to improve this condition.
In 1935 Clive McCay published a paper demonstrating the pro-longevity effects of caloric restriction that would come to shape the future of longevity research. In McCay’s study, a simple 30% reduction of normal caloric intake was shown to impart robust gains in...
5-Minute Daily Breathing Therapy as Effective in Reducing High Blood Pressure and Risk of Cardiovascular Disease as 150 minutes per Week of Moderate Exercise
A modified version of a technique known as inspiratory muscle strength training (IMST), a therapy originally developed to treat pulmonary disorders (e.g., COPD, sleep apnea), is showing significant potential in replicating various effects of daily exercise with to regard to cardiovascular health.
In a paper published in Royal Society Open Science, Beros et al. detail an example of the extreme lifespan extension imparted to normally short-lived worker ants that have been infected by the tapeworm Anomotaenia brevis.
OFAS Associate Scientist Dr. Sailendra Nichenametla will chair a webinar, "Sulfur Amino Acid Restriction - Moving from Animals to Humans", for Aging Science Talks on October 20-21, 2021. The sessions will include presentations by Dr. Nichenametla, OFAS Associate...
OFAS presented the second Dr. Norman Orentreich Award for Young Investigator on Aging to Dr. Cristal Hill of the Pennington Biomedical Research Center. In addition to the $1,000 prize, Cristal was invited to present at the 2021 OFAS Symposium on Healthy Aging.
Researchers from Mayo Clinic have uncovered a novel way in which exercise may contribute to healthy aging by suppressing an age-related phenomenon known as the senescence-associated secretory phenotype, or SASP. In recent years, research has uncovered a number of...
A post-doctoral position at the Orentreich Foundation for the Advancement of Science (Cold Spring-on-Hudson, NY) is immediately available in Dr. Sailendra Nichenametla’s lab.
Supplementation of the nutrient selenium protects against diet-induced obesity and may extend the lifespan of mice by controlling energy-regulating hormones.