Canine Companions: Paving the Way for Human Aging Treatments

Canine Companions: Paving the Way for Human Aging Treatments

The FDA’s approval of LOY-003 for a phase I clinical trial, aiming to delay aging in dogs, marks a groundbreaking step in aging research. This move reflects the ongoing debate about classifying aging as a disease and the challenges of establishing clear endpoints for clinical trials targeting the aging process. This could lead to significant advancements in treatments for aging in humans, highlighting the potential for these findings to inform future human trials and alter our approach to managing aging and extending healthy lifespan.

Unlocking the Secrets of Naked Mole-Rats: Pro-longevity Effects of Hyaluronic Acid

Unlocking the Secrets of Naked Mole-Rats: Pro-longevity Effects of Hyaluronic Acid

Naked mole-rats, peculiar-looking creatures that live in underground colonies, have fascinated scientists for years. How do naked mole-rats stay youthful and healthy for so long? In this article, we delve into the unique nature of these creatures, exploring the latest research that may unlock the secrets behind their extraordinary longevity and resilience.

Research Position Available

Dr. Nichenametla’s lab is hiring a Senior Technician or a Senior Post-doctoral Fellow. The candidate will work on various SAAR-related projects associated with mechanisms, nutritional aspects, and prevention of diseases, including metabolic diseases, cancers, and proteostatic disorders. Responsibilities include generating data extensively from rodent models and occasionally from in vitro studies and clinical study specimens. Routine daily activities include performing experiments and data analysis, drafting publication-quality manuscripts, assisting in submitting grant proposals, and presenting work at scientific meetings. For more information, click here

Putting the Brakes on DNA Transcription to Slow the Aging Process

Putting the Brakes on DNA Transcription to Slow the Aging Process

A recent investigation into the molecular mechanisms underlying animal aging provides insights into potential preventive measures. The findings reveal a novel aspect of aging, characterized by an age-related escalation in the pace at which DNA is transformed into RNA and its impact on subsequently translated functional proteins.

Sailendra Nichenametla Recipient of Inaugural Hevolution/AFAR New Investigator Award in Aging Biology and Geroscience

Sailendra Nichenametla Recipient of Inaugural Hevolution/AFAR New Investigator Award in Aging Biology and Geroscience

Senior Scientist Sailendra Nichenametla, Ph.D., has been named as a recipient of the inaugural Hevolution/AFAR New Investigator Awards in Aging Biology and Geroscience Research, presented by the American Federation for Aging Research (AFAR) and Hevolution Foundation. The US$375,000 award supports research projects in basic biology of aging or geroscience—a research paradigm based on addressing the biology of aging and age-related disease to promote healthy aging. Dr. Nichenametla will utilize the funds to investigate the role of serinogenesis in regulating lipid metabolism.

Serine Supplementation Could Mitigate Cognitive Impairments of an Aging Hypothalamus

Serine Supplementation Could Mitigate Cognitive Impairments of an Aging Hypothalamus

Age-related decline in menin has led researchers to consider its role in the context of aging. Their findings revealed that decreasing menin in younger mice resulted in elevated hypothalamic neuroinflammation and several aging-related characteristics such as decreased bone mass and skin thickness, cognitive decline, and a slightly reduced lifespan.

Can Ultrasound Therapy Delay Aging?

Can Ultrasound Therapy Delay Aging?

Researchers from the University of Texas have provided preliminary evidence for a mechanical method to reduce the burden of senescent cells utilizing a low-cost, non-invasive application of low-frequency ultrasound therapy.

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