Ables Lab

Gene P. Ables, Ph.D.

Associate Scientist

 

 

 

Dr. Ables received his degree of Doctor of Veterinary Medicine from the University of the Philippines. He then obtained his PhD from Hokkaido University (Japan). His post-doctoral research in Preventive Medicine and Nutrition at Columbia University focused on liver lipid metabolism. In 2006, he was appointed Associate Research Scientist at the Columbia University Medical Center. Dr. Ables joined OFAS in April 2011 as a Senior Scientist, and in 2015 he was appointed Associate Science Director. He leads staff in investigations of the methionine-restricted diet’s effects on metabolism, cancer, and epigenetics.

Dr. Ables continues to investigate the effects of sulfur amino acid restriction (SAAR) on neurodegenerative diseases using a mouse model for amyotrophic lateral sclerosis amyotrophic lateral sclerosis (ALS), commonly known as Lou Gehrig’s disease. ALS is a progressive and fatal neuromuscular disease characterized by neuroinflammation progressing to neurodegeneration. No cure for ALS has yet been identified, and there is a dearth of proven useful therapeutic interventions. One of the causes of neuronal death in ALS is oxidative damage, something SAAR in rodents has shown to beneficially effect. However, the effect of SAAR on neurological systems using a mouse disease model such as ALS has not yet been examined. To investigate this, Dr. Ables’s lab is conducting experiments on transgenic mice transfected with the ALS-associated G93A human superoxide dismutase 1 mutation, SOD1-G93A. They are in the process of analyzing data on the mechanisms by which SAAR effects the onset of disease, measured by various strength and agility tests. They are also analyzing whether SAAR suppresses disease progression by attenuation of inflammation and oxidative stress markers in neurons and muscle cells. Characterization of the effects of SAAR in SOD1-G93A mice is the first step that will direct future investigations of how SAAR may affect other neurological diseases.
Ph.D. Hokkaido University

D.V.M. University of the Philippines

Diana Cooke in the laboratory

Diana Cooke, Senior Research Associate

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