Gene P. Ables, Ph.D.
Dr. Ables received his degree of Doctor of Veterinary Medicine from the University of the Philippines. He then obtained his PhD from Hokkaido University (Japan). His post-doctoral research in Preventive Medicine and Nutrition at Columbia University focused on liver lipid metabolism. In 2006, he was appointed Associate Research Scientist at the Columbia University Medical Center. Dr. Ables joined OFAS in April 2011 as a Senior Scientist, and in 2015 he was appointed Associate Science Director. He leads staff in investigations of the methionine-restricted diet’s effects on metabolism, cancer, and epigenetics.
D.V.M. University of the Philippines
- Weight loss and concomitant adipose autophagy in methionine-restricted obese mice is not dependent on adiponectin or FGF21
Cooke D, Mattocks DAL, Nichenametla SN, Anunciado-Koza RP, Koza RA, Ables GP
Obesity 2020; 28 (6): 1075-1085| PubMed ID: 32348021Dietary methionine influences therapy in mouse cancer models and alters human metabolism.
Gao X, Sanderson SM, Dai Z, Reid MA, Cooper DE, Lu M, Richie JP Jr, Ciccarella A, Calcagnotto A, Mikhael PG, Mentch SJ, Liu J, Ables G, Kirsch DG, Hsu DS, Nichenametla SN, Locasale JW
Nature 2019; 572 (7769): 397-401| PubMed ID: 31367041Bone marrow adiposity: basic and clinical implications
Sebo ZL, Rendina-Ruedy E, Ables GP, Lindskog DM, Rodeheffer MS, Fazeli PK, Horowitz MC
Endocrine Reviews 2019; 40 (5): 1187-1206| PubMed ID: 31127816Identification and application of gene expression signatures associated with lifespan extension
Tyshkovskiy A, Bozaykut P, Borodinova AA, Gerashchenko MV, Ables GP, Garratt M, Khaitovich P, Clish CB, Miller RA, Gladyshev VN.
Cell Metabolism 2019; 30 (3): 573-593.e8| PubMed ID: 31353263 Bone marrow adipocytes.
Horowitz MC, Berry R, Holtrup B, Sebo Z, Nelson T, Fretz JA, Lindskog D, Kaplan JL, Ables GP, Rodeheffer MS, Rosen CJ.
Adipocytes 2017; 6 (3): 193-204| PubMed ID: 28872979Dietary methionine restriction modulates renal response and attenuates kidney injury in mice
Cooke D, Ouattara A, Ables GP
The FASEB Journal 2017; 32 (2): 693-702| PubMed ID: 28970255Pleiotropic responses to methionine restriction
Ables GP, Johnson JE
Experimental Gerontology 2017; (94): 83-88| PubMed ID: 28108330Methionine restriction alters bone morphology and affects osteoblast differentiation
Ouattara A, Cooke D, Gopalakrishnan R, Huang TH, Ables GP
Bone Reports 2016; 5: 33-42| PubMed ID: 28326345Methionine restriction beyond life-span extension
Ables GP, Hens JR, Nichenametla SN
Annals of the New York Academy of Sciences 2016; 1363 (1): 68-79| PubMed ID: 26916321Dietary restrictions, bone density, and bone quality
Huang TH, Ables GP
Annals of the New York Academy of Sciences 2016; 1363 (1): 26-39| PubMed ID: 26881697Histone methylation dynamics and gene regulation occur through the sensing of one-carbon metabolism
Mentch SJ, Mehrmohamadi M, Huang L, Liu X, Gupta D, Mattocks D, Gόmez Padilla P, Ables G, Bamman MM, Thalacker-Mercer AE, Nichenametla SN, Locasale JW
Cell Metabolism 2015; 22 (5): 861-73| PubMed ID: 26411344Effects of methionine restriction and endurance exercise on bones of ovariectomized rats: a study of histomorphometry, densitometry, and biomechanical properties
Huang TH, Su IH, Lewis JL, Chang MS, Hsu AT, Perrone CE, Ables GP
Journal of Applied Physiology (Bethesda, Md. : 1985) 2015; 119 (5): 517-26| PubMed ID: 26159761Dietary methionine restriction in mice elicits an adaptive cardiovascular response to hyperhomocysteinemia
Ables GP, Ouattara A, Hampton TG, Cooke D, Perodin F, Augie I, Orentreich DS
Scientific Reports 2015; 5: 8886| PubMed ID: 25744495A methionine-restricted diet and endurance exercise decrease bone mass and extrinsic strength but increase intrinsic strength in growing male rats
Huang TH, Lewis JL, Lin HS, Kuo LT, Mao SW, Tai YS, Chang MS, Ables GP, Perrone CE, Yang RS
The Journal of Nutrition 2014; 144 (5): 621-30| PubMed ID: 24647387The First International Mini-Symposium on Methionine Restriction and Lifespan
Ables GP, Brown-Borg HM, Buffenstein R, Church CD, Elshorbagy AK, Gladyshev VN, Huang TH, Miller RA, Mitchell JR, Richie JP, Rogina B, Stipanuk MH, Orentreich DS, Orentreich N
Frontiers in Genetics 2014; 5: 122| PubMed ID: 24847356Methionine restriction prevents the progression of hepatic steatosis in leptin-deficient obese mice
Malloy VL, Perrone CE, Mattocks DA, Ables GP, Caliendo NS, Orentreich DS, Orentreich N
Metabolism: Clinical and Experimental 2013; 62 (11): 1651-61| PubMed ID: 23928105Update on pparγ and nonalcoholic Fatty liver disease
PPAR Research 2012; 2012: 912351| PubMed ID: 22966224Methionine-restricted C57BL/6J mice are resistant to diet-induced obesity and insulin resistance but have low bone density
Ables GP, Perrone CE, Orentreich D, Orentreich N
PloS One 2012; 7 (12): e51357| PubMed ID: 23236485